Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 4/20 | 0.46 |
| ▸ | CNR2 | P34972 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23024544 | 1.00 | MAPT (0.53) | MAPTKDM4ELMNASMN1; SMN2THRB | |
| SCHEMBL3698011 | 0.90 | MAPT (0.49) | MAPTKDM4ELMNASMN1; SMN2THRB | |
| SCHEMBL5340205 | 0.84 | CHRNA7 (0.61) | MAPTKDM4ELMNATHRBCHRNA7 | |
| SCHEMBL16876828 | 0.84 | CHRNA7 (0.54) | MAPTKDM4ELMNASMN1; SMN2THRB | |
| SCHEMBL30529660 | 0.82 | L3MBTL1 (0.51) | L3MBTL1CNR1CNR2KMT2A | |
| SCHEMBL23024350 | 0.82 | L3MBTL1 (0.51) | L3MBTL1CNR1CNR2KMT2A | |
| SCHEMBL9205210 | 0.81 | CHRNA7 (0.54) | MAPTKDM4ELMNASMN1; SMN2THRB | |
| SCHEMBL3700471 | 0.81 | THRB (0.48) | MAPTKDM4ELMNASMN1; SMN2THRB | |
| SCHEMBL9210328 | 0.80 | CHRNA7 (0.63) | MAPTKDM4ELMNASMN1; SMN2CHRNA7 | |
| SCHEMBL23354929 | 0.80 | KDM4E (0.45) | MAPTKDM4ELMNASMN1; SMN2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117263942-A | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-112166110-B | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-08-11 | — | — | CN | disclosed |