Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.63 |
| ▸ | CA9 | Q16790 | 3/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9211545 | 0.89 | CHRNA7 (0.59) | CHRNA7CA9NR1H2PTGS2PTGS1 | |
| SCHEMBL7627415 | 0.87 | CHRNA7 (0.83) | CHRNA7CA9PTGS2PTGS1AOC3 | |
| SCHEMBL16876828 | 0.85 | CHRNA7 (0.54) | CHRNA7CA9PTGS2KDM4ELMNA | |
| SCHEMBL9212272 | 0.85 | MARS1 (0.55) | CHRNA7PTGS2PTGS1AOC3 | |
| SCHEMBL9205210 | 0.85 | CHRNA7 (0.54) | CHRNA7CA9PTGS2KDM4ELMNA | |
| SCHEMBL9208779 | 0.84 | PTGS2 (0.51) | CHRNA7PTGS2PTGS1AOC3 | |
| SCHEMBL9201606 | 0.84 | CHRNA7 (0.66) | CHRNA7CA9NR1H2PTGS2PTGS1 | |
| SCHEMBL7872897 | 0.82 | CHRNA7 (0.66) | CHRNA7CA9NR1H2PTGS2SMN1; SMN2 | |
| SCHEMBL7872745 | 0.82 | CHRNA7 (0.66) | CHRNA7CA9NR1H2PTGS2SMN1; SMN2 | |
| SCHEMBL23024544 | 0.80 | MAPT (0.53) | CHRNA7KDM4ELMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |