Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 4/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30853317 | 0.76 | FGFR4 (0.44) | PIK3CAMTORJAK2PRKDCPIK3CG | |
| SCHEMBL25462291 | 0.73 | HPGD (0.41) | MAPK1 | |
| SCHEMBL28655766 | 0.68 | PIK3CA (0.35) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL26160595 | 0.65 | JAK2 (0.57) | MTORJAK2PRKDCJAK1HCAR1 | |
| SCHEMBL4044760 | 0.65 | PDE3B (0.48) | PIK3CG | |
| SCHEMBL152295 | 0.64 | MTOR (0.59) | PIK3CAMTORJAK2PRKDC | |
| SCHEMBL29522157 | 0.64 | MTOR (0.59) | PIK3CAMTORJAK2PRKDC | |
| SCHEMBL14042006 | 0.64 | PDE3B (0.46) | — | |
| SCHEMBL151621 | 0.64 | MTOR (0.57) | PIK3CAMTORJAK2PRKDC | |
| SCHEMBL30030188 | 0.63 | MAPK8 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113912608-B | Pyrimidopyrimidinone derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2023-07-14 | — | — | CN | disclosed |