Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SNCA | P37840 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 3/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.39 |
| ▸ | ABAT | P80404 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7786706 | 0.83 | ALDH1A1 (0.50) | ALDH1A1CYP3A4PDK1MAPK1TSHR | |
| SCHEMBL305109 | 0.81 | ALDH1A1 (0.55) | ALDH1A1SNCACYP3A4ALOX15ALOX12 | |
| SCHEMBL14928472 | 0.80 | TSHR (0.42) | ALDH1A1CYP3A4GPR35PDK1MAPK1 | |
| SCHEMBL1425442 | 0.79 | ALDH1A1 (0.50) | ALDH1A1CYP3A4PDK1MAPK1TSHR | |
| SCHEMBL12658937 | 0.79 | PDK1 (0.45) | ALDH1A1SNCACYP3A4ALOX15ALOX12 | |
| SCHEMBL11555308 | 0.79 | ALDH1A1 (0.69) | ALDH1A1SNCACYP3A4ALOX15ALOX12 | |
| SCHEMBL6028713 | 0.79 | SNCA (0.50) | ALDH1A1SNCACYP3A4ALOX15ALOX12 | |
| SCHEMBL305329 | 0.78 | ALDH1A1 (0.49) | ALDH1A1CYP3A4ALOX15GPR35MAPK1 | |
| SCHEMBL12776823 | 0.77 | SNCA (0.74) | ALDH1A1SNCACYP3A4ALOX15ALOX12 | |
| SCHEMBL11127500 | 0.77 | PDK1 (0.46) | ALDH1A1SNCACYP3A4ALOX15ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103339112-A | Topical antifungal agent | MEIJI SEIKA PHARMA CO LTD | 2013-10-02 | — | — | CN | disclosed |
| US-8093244-B2 | Heteroaryl urea derivatives useful for inhibiting CHK1 | ICOS CORPORATION (US) | 2012-01-10 | — | — | US | disclosed |
| CN-102219784-A | Heteroaryl urea derivatives useful for inhibition of CHK1 | ICOS CORP | 2011-10-19 | — | — | CN | disclosed |
| CN-101151259-B | Heteroaryl urea derivatives useful for inhibition of CHK1 | ICOS CORP | 2011-06-15 | — | — | CN | disclosed |
| EP-2330105-A1 | Heteroaryl urea derivatives useful for inhibiting CHK1 | ICOS Corporation (US) | 2011-06-08 | — | — | EP | disclosed |
| US-20090143357-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS CORPORATION (US) | 2009-06-04 | — | — | US | disclosed |
| CN-101151259-A | Heteroaryl urea derivatives useful for inhibition of CHKI | ICOS CORP (US) | 2008-03-26 | — | — | CN | disclosed |
| EP-1869020-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl | ICOS Corporation (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105262-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl | ICOS CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143357-A1 | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | CHEK1, CHEK2, PCNA | ALDH1A1 3398/4885SNCA 2302/4885CYP3A4 3803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.