Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.57 |
| ▸ | HTR2A | P28223 | 8/20 | 0.57 |
| ▸ | HTR2C | P28335 | 8/20 | 0.57 |
| ▸ | HTR2B | P41595 | 8/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29447988 | 1.00 | SIGMAR1 (0.57) | SIGMAR1HTR2AHTR2CHTR2BCES1 | |
| SCHEMBL31298536 | 0.87 | HTR2A (0.47) | SIGMAR1HTR2AHTR2CHTR2BCES1 | |
| SCHEMBL14358027 | 0.82 | SIGMAR1 (0.56) | SIGMAR1HTR2AHTR2CHTR2BCES1 | |
| SCHEMBL6448738 | 0.81 | SIGMAR1 (0.54) | SIGMAR1HTR2AHTR2CHTR2BCES1 | |
| SCHEMBL8000122 | 0.81 | SIGMAR1 (0.54) | SIGMAR1HTR2AHTR2CHTR2BCES1 | |
| SCHEMBL11242114 | 0.79 | SIGMAR1 (0.53) | SIGMAR1HTR2AHTR2CHTR2BCES1 | |
| SCHEMBL29661169 | 0.79 | NPSR1 (0.50) | SIGMAR1HTR2AHTR2CHTR2BCES1 | |
| SCHEMBL1745254 | 0.79 | NPSR1 (0.50) | SIGMAR1HTR2AHTR2CHTR2BCES1 | |
| SCHEMBL5608198 | 0.78 | SIGMAR1 (0.51) | SIGMAR1HTR2AHTR2CHTR2BCES1 | |
| SCHEMBL18494326 | 0.78 | SIGMAR1 (0.74) | SIGMAR1HTR2AHTR2CHTR2BCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113563167-A | Preparation method of 2-methyl-1-tetralone | 南通华祥医药科技有限公司 | 2021-10-29 | — | — | CN | claimed |
| CN-105198722-A | Method for asymmetrically catalyzing and synthesizing (R)-4, 7-dimethyl-1-tetralone | UNIV CHINA AGRICULTURAL | 2015-12-30 | — | — | CN | claimed |
| US-8969249-B2 | Synthesis and biological activity of bicyclic ABA analogs | NATIONAL RESEARCH COUNCIL OF CANADA | 2015-03-03 | — | — | US | claimed |
| US-20080200339-A1 | Methylating 1-tetralone to produce dimethyl tetralone or reacting 2-methyl-1-naphthol, alkylating with 3-methylpent-2-en-4-yn-1-ol, oxidizing the alcohol to an ester, reacting the ester or deprotecting the ketal to give a ketone; inhibiting cell growth and seed germination; herbicides | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2008-08-21 | — | — | US | claimed |
| WO-2005108345-A1 | SYNTHESIS AND BIOLOGICAL ACTIVITY OR NOVEL BICYCLIC ABA ANALOGS | NATIONAL RESEARCH COUNCIL OF CANADA (CA) | 2005-11-17 | — | — | WO | claimed |
| US-20230055376-A1 | 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE | ARENA PHARMACEUTICALS, INC. | 2023-02-23 | — | — | US | disclosed |
| US-20230055376-A1 | 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE | ARENA PHARMACEUTICALS, INC. | 2023-02-23 | — | — | US | disclosed |
| EP-3328835-B1 | 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE | ARENA PHARM INC (US) | 2022-10-12 | — | — | EP | disclosed |
| CN-115003662-A | Odorants and compositions comprising odorants | 丝趣科尔卡有限公司 | 2022-09-02 | — | — | CN | disclosed |
| US-11395824-B2 | 5-HT2C receptor agonists and compositions and methods of use | ARENA PHARMACEUTICALS, INC. (US) | 2022-07-26 | — | — | US | disclosed |
| CN-114262250-A | Synthetic method of aromatic ring benzyl ortho-position dialkyl | 乐威医药（江苏）股份有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-113862034-A | Method for synthesizing high-density aviation kerosene from biomass diene and p-benzoquinone in one pot | 中国科学院大连化学物理研究所 | 2021-12-31 | — | — | CN | disclosed |
| CN-1162918-A | Depressant of functions developed by molecule | KOYAMA SHOZO (JP) | 1997-10-22 | — | — | CN | disclosed |
| EP-0780122-A1 | DEPRESSANT OF FUNCTIONS DEVELOPED BY MOLECULE | Koyama, Shozo (JP) | 1997-06-25 | — | — | EP | disclosed |
| CN-1151744-A | Phosphonic acid compounds, their prodn. and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-06-11 | — | — | CN | disclosed |
| EP-0769015-A1 | PHOSPHONIC ACID COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-04-23 | — | — | EP | disclosed |
| US-5493012-A | Ion triggered alkylation of biological targets by silyloxy aromatic agents | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1996-02-20 | — | — | US | disclosed |
| WO-1996001267-A1 | PHOSPHONIC ACID COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-01-18 | — | — | WO | disclosed |
| CN-1068814-A | Tetracyclic antibiotic and manufacture method thereof | HOECHST AG (DE) | 1993-02-10 | — | — | CN | disclosed |
| CN-1058208-A | PHARMACEUTICAL COMPOUNDS | WELLCOME FOUND (GB) | 1992-01-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200339-A1 | Methylating 1-tetralone to produce dimethyl tetralone or reacting 2-methyl-1-naphthol, alkylating with 3-methylpent-2-en-4-yn-1-ol, oxidizing the alcohol to an ester, reacting the ester or deprotecting the ketal to give a ketone; inhibiting cell growth and seed germination; herbicides | FASN, HACL2, ACSL1 | SIGMAR1 4301/4885HTR2A 4445/4885HTR2C 3758/4885 |
| US-20230055376-A1 | 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE | HTR2C, HTR2A, HCRTR2 | SIGMAR1 551/4885HTR2A 2/4885HTR2C 1/4885 |
| US-11395824-B2 | 5-HT2C receptor agonists and compositions and methods of use | HTR2C, HTR2A, HCRTR2 | SIGMAR1 551/4885HTR2A 2/4885HTR2C 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.