Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 5/20 | 0.35 |
| ▸ | CHUK | O15111 | 4/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 9/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30540478 | 0.87 | GRM2 (0.39) | PDPK1IKBKBCHUKGRM2LMNA | |
| SCHEMBL30540623 | 0.87 | KEAP1 (0.35) | — | |
| Lithium SCHEMBL31115355 | 0.85 | KEAP1 (0.34) | — | |
| Lithium Ion SCHEMBL30540604 | 0.84 | JAK3 (0.32) | — | |
| SCHEMBL30540544 | 0.82 | MAPK1 (0.37) | LMNAMAPK1NQO2 | |
| SCHEMBL30540619 | 0.70 | NQO1 (0.33) | — | |
| SCHEMBL30577623 | 0.69 | MAPK1 (0.38) | LMNAMAPK1NQO2 | |
| SCHEMBL5313016 | 0.67 | IKBKB (0.46) | PDPK1IKBKBCHUKLMNABTK | |
| SCHEMBL19925316 | 0.66 | MAOB (0.40) | PDPK1LMNABTKMAPK1 | |
| SCHEMBL30540624 | 0.66 | MAOB (0.40) | PDPK1LMNABTKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4476219-A1 | HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | BeiGene, Ltd. (KY) | 2024-12-18 | — | — | EP | disclosed |
| CN-118696043-A | Heterocyclic compounds, compositions thereof and methods of treatment therewith | 百济神州有限公司 | 2024-09-24 | — | — | CN | disclosed |
| WO-2023151636-A1 | HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | BEIGENE , LTD. (KY) | 2023-08-17 | — | — | WO | disclosed |
| WO-2023151641-A1 | HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | BEIGENE , LTD. (KY) | 2023-08-17 | — | — | WO | disclosed |