Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 15/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 12/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25365515 | 1.00 | CYP11B2 (0.45) | CYP11B2CYP11B1KDM4EHSD17B10NPC1 | |
| SCHEMBL31578438 | 0.77 | JAK2 (0.47) | CYP11B2CYP11B1 | |
| SCHEMBL25366422 | 0.77 | JAK2 (0.47) | CYP11B2CYP11B1 | |
| SCHEMBL25363473 | 0.75 | ALDH1A1 (0.38) | CYP11B2CYP11B1KDM4EALDH1A1HPGD | |
| SCHEMBL25364307 | 0.74 | PRKDC (0.37) | CYP11B2CYP11B1KDM4EHSD17B10NPC1 | |
| SCHEMBL25365595 | 0.73 | ALDH1A1 (0.39) | CYP11B2CYP11B1KDM4EHSD17B10NPC1 | |
| SCHEMBL25364198 | 0.73 | TGFBR1 (0.37) | CYP11B2CYP11B1KDM4EALDH1A1HPGD | |
| SCHEMBL25367831 | 0.72 | TLR9 (0.38) | CYP11B2CYP11B1KDM4EHSD17B10NPC1 | |
| SCHEMBL20337775 | 0.71 | CYP11B1 (0.70) | CYP11B2CYP11B1 | |
| SCHEMBL30777241 | 0.71 | CYP11B1 (0.70) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4479407-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | Bristol-Myers Squibb Company (US) | 2024-12-25 | — | — | EP | disclosed |
| WO-2023159153-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-24 | — | — | WO | disclosed |