Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL29248942 | 0.89 | RNASEH1 (0.37) | TDP1SMN1; SMN2ALDH1A1GAAKDM4E | |
| SCHEMBL24257827 | 0.85 | RNASEH1 (0.47) | TDP1L3MBTL1SMN1; SMN2MAPTLMNA | |
| SCHEMBL30452343 | 0.85 | RNASEH1 (0.47) | TDP1L3MBTL1SMN1; SMN2MAPTLMNA | |
| SCHEMBL30454412 | 0.84 | RNASEH1 (0.40) | TDP1SMN1; SMN2ALDH1A1GAAKDM4E | |
| SCHEMBL24257810 | 0.84 | RNASEH1 (0.40) | TDP1SMN1; SMN2ALDH1A1GAAKDM4E | |
| SCHEMBL30452335 | 0.80 | PPID (0.43) | TDP1L3MBTL1MAPTRAB9ALMNA | |
| SCHEMBL24257784 | 0.80 | PPID (0.43) | TDP1L3MBTL1MAPTRAB9ALMNA | |
| SCHEMBL24257456 | 0.79 | EGLN1 (0.48) | — | |
| Formic Acid SCHEMBL30454433 | 0.76 | EGLN1 (0.45) | — | |
| SCHEMBL29248940 | 0.75 | ALDH1A1 (0.35) | TDP1L3MBTL1SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116670131-A | PHD inhibitor compounds, compositions, and methods of use | 阿克比治疗有限公司 | 2023-08-29 | — | — | CN | disclosed |