Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25257194 | 1.00 | POLB (0.60) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL10112710 | 0.78 | POLB (0.56) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL22569116 | 0.77 | HTT (0.78) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL15562080 | 0.77 | HCAR2 (0.60) | HCAR2KDM4EALOX15RAB9ASMN1; SMN2 | |
| SCHEMBL8490044 | 0.77 | POLB (0.55) | POLBHCAR2KDM4EHTTALOX15 | |
| Formaldehyde SCHEMBL27682220 | 0.76 | HCAR2 (0.92) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL28801075 | 0.75 | POLB (0.69) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL112388 | 0.75 | HCAR2 (1.00) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL29603529 | 0.75 | HCAR2 (1.00) | POLBHCAR2KDM4EHTTALOX15 | |
| SCHEMBL27623883 | 0.74 | POLB (0.56) | POLBHCAR2KDM4EHTTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |