SCHEMBL305498

SCHEMBL305498

O=C(Nc1ccccc1)Nc1ccncc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 1.00
MDM2 Q00987 1/20 0.83
SMN1; SMN2 Q16637 4/20 0.74
TP53 P04637 1/20 0.74
EPHX1 P07099 1/20 0.74
TSHR P16473 1/20 0.74
EPHX2 P34913 1/20 0.74
CDK9 P50750 1/20 0.74
CLK4 Q9HAZ1 1/20 0.74
LMNA P02545 1/20 0.68
KMT2A Q03164 4/20 0.66
MEN1 O00255 3/20 0.66
HTT P42858 2/20 0.66
POLB P06746 1/20 0.66
PKM P14618 1/20 0.66
JAK2 O60674 1/20 0.66
TYK2 P29597 1/20 0.66
CASP3 P42574 1/20 0.63
SENP7 Q9BQF6 1/20 0.63
BCHE P06276 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25825682 0.92 TAAR1 (0.85) TAAR1MDM2SMN1; SMN2TP53EPHX1
SCHEMBL23069097 0.92 TAAR1 (0.85) TAAR1MDM2SMN1; SMN2TP53EPHX1
SCHEMBL10020286 0.91 MDM2 (1.00) TAAR1MDM2SMN1; SMN2EPHX1LMNA
SCHEMBL31668740 0.89 MDM2 (0.95) TAAR1MDM2SMN1; SMN2EPHX1LMNA
Diphenylurea SCHEMBL133103 0.86 SMN1; SMN2 (1.00) TAAR1SMN1; SMN2TP53EPHX1TSHR
Diphenylurea SCHEMBL3037927 0.84 SMN1; SMN2 (0.94) TAAR1SMN1; SMN2TP53EPHX1TSHR
Diphenylurea SCHEMBL29392345 0.84 SMN1; SMN2 (0.94) TAAR1SMN1; SMN2TP53EPHX1TSHR
Diphenylurea SCHEMBL28431956 0.84 SMN1; SMN2 (0.94) TAAR1SMN1; SMN2TP53EPHX1TSHR
Diphenylurea SCHEMBL30786615 0.84 SMN1; SMN2 (0.94) TAAR1SMN1; SMN2TP53EPHX1TSHR
SCHEMBL11059378 0.84 SMN1; SMN2 (0.94) TAAR1SMN1; SMN2TP53EPHX1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115530076-B Winter jujube tissue culture method 山东滨州国家农业科技园区管理服务中心(滨州黄河三角洲高效生态产业现代技术研究院) 2023-05-26 CN claimed
CN-115530076-A Winter jujube tissue culture method 山东滨州国家农业科技园区管理服务中心(滨州黄河三角洲高效生态产业现代技术研究院) 2022-12-30 CN claimed
EP-2430013-B1 HETEROARYL COMPOUNDS AS PIKK INHIBITORS AMGEN INC (US) 2014-10-15 EP claimed
US-20120190666-A1 Heteroaryl Compounds as PIKK Inhibitors AMGEN INC. (US) 2012-07-26 US claimed
EP-2430013-A1 HETEROARYL COMPOUNDS AS PIKK INHIBITORS Amgen, Inc (US) 2012-03-21 EP claimed
WO-2010132598-A1 HETEROARYL COMPOUNDS AS PIKK INHIBITORS AMGEN INC. (US) 2010-11-18 WO claimed
CN-101723886-A Method for synthesizing 1-(4-pyridyl)-3-phenylurea UNIV NORTHWEST A&F 2010-06-09 CN claimed
US-20080196121-A1 Commercially viable process for in vitro mass culture of jatropha curcas RELIANCE LIFE SCIENCES PVT. LTD. (IN) 2008-08-14 US claimed
US-20080194026-A1 COMMERCIALLY VIABLE PROCESS FOR IN VITRO MASS CULTURE OF JATROPHA CURCAS RELIANCE LIFE SCIENCES PVT, LTD. (IN) 2008-08-14 US claimed
EP-1817956-A2 Commercially viable process for in-vitro mass culture of jatropha curcas Reliance Life Sciences Pvt., Ltd. (IN) 2007-08-15 EP claimed
EP-0519758-A1 Hyperproduction of shoots during in vitro regeneration of plant UNIVERSITY OF GUELPH (CA) 1992-12-23 EP claimed
JP-62106003-A None JP disclosed
JP-62108802-A None JP disclosed
JP-11332575-A None JP disclosed
US-20260109845-A1 SHAPE MEMORY POLYMER AND RESIN COMPOSITION THEREOF NANO & ADVANCED MATERIALS INST LTD (CN) 2026-04-23 US disclosed
US-4308054-A PLANT GROWTH REGULATORS SATO, SUSUMU (JP) 1981-12-29 US disclosed
US-4242347-A Hypotensive indolylalkylpiperidyl guanidines and isoureas CIBA-GEIGY CORPORATION (US) 1980-12-30 US disclosed
US-4193788-A N-(2-Chloro-4-pyridyl)ureas ISOGAI YO (JP) 1980-03-18 US disclosed
US-4147786-A HYPOTENSIVE CIBA-GEIGY CORPORATION (US) 1979-04-03 US disclosed
US-4073911-A ANTIHYPERTENSIVE AGENTS CIBA-GEIGY CORPORATION (US) 1978-02-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190666-A1 Heteroaryl Compounds as PIKK Inhibitors PIK3CA, PIKFYVE, PIK3CD TAAR1 4675/4885MDM2 1248/4885SMN1; SMN2 3999/4885
US-20260109845-A1 SHAPE MEMORY POLYMER AND RESIN COMPOSITION THEREOF CD69, VSIG8, PUF60 TAAR1 2674/4885MDM2 3478/4885SMN1; SMN2 81/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.