Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 5/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 4/20 | 0.32 |
| ▸ | PDE9A | O76083 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25319462 | 1.00 | RET (0.41) | RETALDH1A1POLBLMNACYP4F2 | |
| SCHEMBL25324455 | 0.87 | RET (0.42) | RETALDH1A1POLBLMNACYP4F2 | |
| SCHEMBL25323920 | 0.87 | RET (0.48) | RETALDH1A1POLBLMNACYP4F2 | |
| SCHEMBL25328103 | 0.83 | RET (0.38) | RETALDH1A1POLBLMNACYP4F2 | |
| SCHEMBL25322203 | 0.77 | ALDH1A1 (0.45) | RETALDH1A1POLBLMNACYP4F2 | |
| SCHEMBL20324247 | 0.76 | CYP4F2 (0.44) | RETALDH1A1POLBLMNACYP4F2 | |
| SCHEMBL29705330 | 0.76 | CYP4F2 (0.41) | RETALDH1A1POLBLMNACYP4F2 | |
| SCHEMBL29705447 | 0.76 | ALDH1A1 (0.39) | RETALDH1A1POLBLMNACYP4F2 | |
| SCHEMBL30860948 | 0.76 | CYP4F2 (0.44) | RETALDH1A1POLBLMNACYP4F2 | |
| SCHEMBL29705440 | 0.76 | ALDH1A1 (0.45) | RETALDH1A1POLBLMNACYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4469455-A1 | COMPOUNDS AND METHODS OF USE | Tango Therapeutics, Inc. (US) | 2024-12-04 | — | — | EP | disclosed |
| CN-119060035-A | Nitrogen-containing polycyclic derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-12-03 | — | — | CN | disclosed |
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |