Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20411743 | 0.83 | RAD51 (0.43) | TNIKTP53NOTUMDHODHKDM4E | |
| SCHEMBL20411744 | 0.82 | TRPV3 (0.40) | TNIKTP53NOTUMKDM4ENPC1 | |
| SCHEMBL17413465 | 0.81 | IKBKB (0.55) | KMT2ANOTUMGSK3BPOLBRAF1 | |
| SCHEMBL13024368 | 0.80 | TNIK (0.47) | TNIKMITFALDH1A1TP53KMT2A | |
| SCHEMBL3488442 | 0.79 | AXL (0.62) | TNIKALDH1A1KMT2ANOTUMKDM4E | |
| SCHEMBL14069232 | 0.79 | SMN1; SMN2 (0.66) | MITFALDH1A1TP53KMT2ANOTUM | |
| SCHEMBL20411755 | 0.79 | NPC1 (0.37) | TNIKMITFALDH1A1TP53KMT2A | |
| SCHEMBL27217312 | 0.79 | CCNB2 (0.47) | TNIKMITFALDH1A1TP53KMT2A | |
| SCHEMBL1854144 | 0.79 | ALDH1A1 (0.70) | TNIKMITFALDH1A1TP53KMT2A | |
| SCHEMBL13426451 | 0.78 | NOTUM (0.50) | NOTUMDHODHNPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1802373-A | Pyrazoloisoquinoline derivatives as kinase inhibitors | AVENTIS PHARMA INC (US) | 2006-07-12 | — | — | CN | claimed |
| CN-108203408-B | Pyrazole compound containing N-aryl sulfonate as well as synthesis and application thereof | 兰州大学 | 2020-07-21 | — | — | CN | disclosed |
| CN-108203408-A | A kind of pyrazole compound containing N- aromatic yl sulphonates and its synthesis and application | 兰州大学 | 2018-06-26 | — | — | CN | disclosed |
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |
| EP-2225211-B1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | DU PONT (US) | 2013-10-02 | — | — | EP | disclosed |
| US-20100267561-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | E. I. DU PONT DE NEMOURS AND COMPANY | 2010-10-21 | — | — | US | disclosed |
| EP-2225211-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | E. I. du Pont de Nemours and Company (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009086041-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-07-09 | — | — | WO | disclosed |
| EP-1761541-A1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| CN-1802373-A | Pyrazoloisoquinoline derivatives as kinase inhibitors | AVENTIS PHARMA INC (US) | 2006-07-12 | — | — | CN | disclosed |
| WO-2005123738-A1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267561-A1 | HERBICIDAL PYRIDAZINONE DERIVATIVES | CYP1A1, CYP1B1, CBR3 | TNIK 2858/4885MITF 3886/4885ALDH1A1 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.