Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21911494 | 1.00 | RORC (0.42) | RORCPDK1PDK2PDK3PDK4 | |
| SCHEMBL25328563 | 0.89 | PDK1 (0.39) | RORCPDK1PDK2PDK3PDK4 | |
| SCHEMBL21831336 | 0.89 | PDK1 (0.39) | RORCPDK1PDK2PDK3PDK4 | |
| SCHEMBL21911495 | 0.85 | TACR1 (0.38) | RORCBACE1GPR119 | |
| SCHEMBL21910267 | 0.83 | KMT2A (0.37) | RORCGPR119 | |
| SCHEMBL30554422 | 0.83 | KMT2A (0.37) | RORCGPR119 | |
| SCHEMBL30554424 | 0.83 | KMT2A (0.37) | RORCGPR119 | |
| SCHEMBL21910374 | 0.81 | TACR1 (0.37) | GPR119 | |
| SCHEMBL30554486 | 0.81 | TACR1 (0.37) | GPR119 | |
| SCHEMBL21910251 | 0.81 | TACR1 (0.34) | RORCBACE1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3814348-B1 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |