Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21831336 | 1.00 | PDK1 (0.39) | PDK1PDK2PDK3PDK4SLC6A3 | |
| SCHEMBL21911494 | 0.89 | RORC (0.42) | PDK1PDK2PDK3PDK4SLC6A3 | |
| SCHEMBL30554466 | 0.89 | RORC (0.42) | PDK1PDK2PDK3PDK4SLC6A3 | |
| SCHEMBL21831643 | 0.80 | L3MBTL1 (0.36) | MGLLALDH1A1MAPT | |
| SCHEMBL25327588 | 0.80 | L3MBTL1 (0.36) | MGLLALDH1A1MAPT | |
| SCHEMBL21831526 | 0.79 | ALDH1A1 (0.38) | LMNAALDH1A1MAPT | |
| SCHEMBL25327934 | 0.79 | MAPK14 (0.33) | RORCMAPT | |
| SCHEMBL21831342 | 0.79 | MAPK14 (0.33) | RORCMAPT | |
| SCHEMBL25327867 | 0.78 | MAPK14 (0.37) | ALDH1A1 | |
| SCHEMBL21831016 | 0.78 | MAPK14 (0.37) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3814348-B1 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |