Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 7/20 | 0.56 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.55 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.55 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.55 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30772456 | 0.86 | TRAP1 (0.56) | TRAP1DPP8DPP9DPP7HSP90B1 | |
| SCHEMBL497487 | 0.86 | TRAP1 (0.56) | TRAP1DPP8DPP9DPP7HSP90B1 | |
| SCHEMBL8227303 | 0.84 | TRAP1 (0.55) | TRAP1DPP8DPP9DPP7HSP90B1 | |
| SCHEMBL8404042 | 0.84 | NOTUM (0.61) | TRAP1DPP8DPP9DPP7HSP90B1 | |
| SCHEMBL8207795 | 0.84 | DPP8 (0.57) | TRAP1DPP8DPP9DPP7HSP90B1 | |
| SCHEMBL8217297 | 0.83 | TRAP1 (0.53) | TRAP1DPP8DPP9DPP7HSP90B1 | |
| SCHEMBL6886590 | 0.81 | DPP8 (0.54) | TRAP1DPP8DPP9DPP7HSP90B1 | |
| SCHEMBL8083813 | 0.80 | DPP8 (0.67) | TRAP1DPP8DPP9DPP7HSP90B1 | |
| SCHEMBL3478866 | 0.80 | DPP8 (0.60) | TRAP1DPP8DPP9DPP7HSP90B1 | |
| SCHEMBL3429846 | 0.80 | DPP8 (0.53) | TRAP1DPP8DPP9DPP7HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204159-A1 | ORGANIC COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2010-08-12 | — | — | US | disclosed |
| EP-2066688-A2 | MACROCYCLIC HCV INHIBITORS AND THEIR USES | Novartis AG (CH) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008033389-A2 | MACROCYCLIC HCV INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204159-A1 | ORGANIC COMPOUNDS AND THEIR USES | OAT, OTC, AOX1 | TRAP1 901/4885DPP8 907/4885DPP9 1218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.