Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24672117 | 0.82 | JAK2 (0.43) | JAK2ALDH1A1PIK3CD | |
| SCHEMBL30556396 | 0.76 | SOS1 (0.65) | SOS1 | |
| SCHEMBL1128761 | 0.73 | CYP3A4 (0.45) | JAK2JAK3KDREPHB4EPHA2 | |
| SCHEMBL29861463 | 0.71 | MKNK1 (0.36) | PIK3CDPOLBSOS1 | |
| SCHEMBL23326447 | 0.71 | MKNK1 (0.36) | PIK3CDPOLBSOS1 | |
| SCHEMBL15516633 | 0.71 | PDE8B (0.40) | JAK2JAK3TSHRLMNAMEN1 | |
| SCHEMBL15516634 | 0.71 | PDE8B (0.40) | JAK2JAK3TSHRLMNAMEN1 | |
| SCHEMBL23326885 | 0.71 | SOS1 (0.57) | SOS1 | |
| SCHEMBL29910302 | 0.71 | SOS1 (0.57) | SOS1 | |
| SCHEMBL30611941 | 0.71 | ALDH1A1 (0.39) | JAK2KDREPHB4EPHA2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669738-A | Pyrimidopyridone derivative as SOS1 inhibitor, and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2023-08-29 | — | — | CN | disclosed |