Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3046707 | 0.91 | PKM (0.56) | PKMALDH1A1NR1I2CNR2CNR1 | |
| SCHEMBL4748504 | 0.84 | PKM (0.77) | PKMALDH1A1NR1I2CNR2CNR1 | |
| SCHEMBL2841823 | 0.81 | PKM (1.00) | PKMALDH1A1NR1I2CNR2BRD4 | |
| SCHEMBL19911400 | 0.80 | PKM (0.60) | PKMALDH1A1NR1I2BRD4KCNH2 | |
| SCHEMBL2377813 | 0.79 | CYP1A2 (0.47) | PKMNR1I2BRD4KMT2AHTT | |
| SCHEMBL3049751 | 0.79 | MAPT (0.55) | PKMALDH1A1NR1I2CNR2CNR1 | |
| SCHEMBL25235605 | 0.79 | PKM (0.53) | PKMALDH1A1NR1I2BRD4KCNH2 | |
| SCHEMBL30166768 | 0.79 | PKM (0.53) | PKMALDH1A1NR1I2BRD4KCNH2 | |
| SCHEMBL23579799 | 0.78 | CYP1A2 (0.43) | PKMALDH1A1NR1I2CNR2CNR1 | |
| SCHEMBL1623128 | 0.78 | AGER (0.64) | ALDH1A1HTTCYP11B1CYP11B2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197591-A1 | 4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES | PFIZER INC | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197591-A1 | 4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES | CDK7, DPYD, DHFR | PKM 2169/4885ALDH1A1 61/4885NR1I2 1047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.