Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 14/20 | 1.00 |
| ▸ | FBP1 | P09467 | 1/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8463078 | 1.00 | GPR17 (1.00) | GPR17FBP1GRIN1 | |
| SCHEMBL13956651 | 0.86 | GPR17 (0.76) | GPR17FBP1 | |
| SCHEMBL266498 | 0.82 | GPR17 (0.70) | GPR17FBP1GRIN1 | |
| SCHEMBL9433429 | 0.81 | GPR17 (0.68) | GPR17FBP1GRIN1 | |
| SCHEMBL28421067 | 0.80 | GPR17 (0.67) | GPR17FBP1GRIN1 | |
| SCHEMBL14739207 | 0.80 | GPR17 (1.00) | GPR17FBP1 | |
| SCHEMBL15463511 | 0.80 | GPR17 (0.66) | GPR17FBP1GRIN1 | |
| SCHEMBL9078111 | 0.79 | GPR17 (0.64) | GPR17FBP1GRIN1 | |
| SCHEMBL9432682 | 0.79 | GRIN1 (0.71) | GPR17FBP1GRIN1 | |
| SCHEMBL9076074 | 0.77 | GPR17 (0.61) | GPR17FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260034138-A1 | NOVEL PYRIMIDINYL AND TRIAZINYL SULFONAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2026-02-05 | — | — | US | disclosed |
| US-20250188061-A1 | NOVEL DEUTERATED PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2025-06-12 | — | — | US | disclosed |
| CN-119731168-A | Deuterated pyrimidin-2-ylsulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-03-28 | — | — | CN | disclosed |
| CN-119585258-A | Novel 7-substituted indole sulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-03-07 | — | — | CN | disclosed |
| CN-119585257-A | Novel 7-substituted indole sulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-03-07 | — | — | CN | disclosed |
| CN-119562950-A | Novel pyrimidinyl and triazinyl sulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-119546576-A | Novel isoquinolinones pyrrolo-pyridones and thieno pyridone sulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-119546572-A | Novel naphthyl and isoquinoline sulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-119546608-A | Novel imidazopyridine and pyrazolopyridine sulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-116829550-A | Pyrimidine-2-ylsulfonamide derivatives | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250188061-A1 | NOVEL DEUTERATED PYRIMIDIN-2-YL SULFONAMIDE DERIVATIVES | DDX41, CDK2, CCNT2 | GPR17 1413/4885FBP1 2853/4885GRIN1 480/4885 |
| US-20260034138-A1 | NOVEL PYRIMIDINYL AND TRIAZINYL SULFONAMIDE DERIVATIVES | GPR180, GPR27, GPR17 | GPR17 3/4885FBP1 4599/4885GRIN1 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.