Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | DUT | P33316 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4894524 | 0.92 | CYP1A2 (0.56) | CYP1A2CYP2C19CYP2C9ALDH1A1TDP1 | |
| SCHEMBL6017107 | 0.88 | CYP1A2 (0.39) | CYP1A2CYP2C19CYP2C9ALDH1A1DUT | |
| SCHEMBL3369737 | 0.88 | CYP1A2 (0.39) | CYP1A2CYP2C19CYP2C9ALDH1A1DUT | |
| SCHEMBL20900528 | 0.82 | TDP1 (0.44) | CYP2C19ALDH1A1TDP1LMNARECQL | |
| SCHEMBL22655811 | 0.82 | HTR2C (0.35) | CYP1A2CYP2C19CYP2C9ALDH1A1DUT | |
| SCHEMBL12634859 | 0.81 | DUT (0.37) | CYP1A2CYP2C19ALDH1A1TDP1LMNA | |
| SCHEMBL14804182 | 0.81 | L3MBTL1 (0.51) | CYP1A2CYP2C19CYP2C9ALDH1A1TDP1 | |
| SCHEMBL30375395 | 0.81 | DUT (0.37) | CYP1A2CYP2C19ALDH1A1TDP1LMNA | |
| SCHEMBL1927440 | 0.81 | HTR7 (0.50) | CYP1A2CYP2C19CYP2C9ALDH1A1TDP1 | |
| SCHEMBL30923921 | 0.80 | CA12 (0.36) | CYP1A2CYP2C19CYP2C9ALDH1A1DUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261679-A1 | CSF-1R, Inhibitors, Compositions, and Methods of Use | NOVARTIS AG (CH) | 2010-10-14 | — | — | US | disclosed |
| US-20100261679-A1 | CSF-1R, Inhibitors, Compositions, and Methods of Use | NOVARTIS AG (CH) | 2010-10-14 | — | — | US | disclosed |
| EP-2211862-A2 | CSF-1R INHIBITORS FOR TREATMENT OF CANCER AND BONE DISEASES | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009050228-A2 | CSF-1R INHIBITORS FOR TREATMENT OF CANCER AND BONE DISEASES | NOVARTIS AG (CH) | 2009-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261679-A1 | CSF-1R, Inhibitors, Compositions, and Methods of Use | CSF1R, CSF3R, MSR1 | CYP1A2 3941/4885CYP2C19 4220/4885CYP2C9 4356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.