SCHEMBL30565749

SCHEMBL30565749

Brc1ccc(-c2ccccc2)c(Br)c1Br

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.54
MAPK1 P28482 2/20 0.54
BACE1 P56817 1/20 0.39
ALOX5 P09917 1/20 0.38
CRHBP P24387 1/20 0.38
CRHR2 Q13324 1/20 0.38
HSD17B10 Q99714 2/20 0.37
HPGD P15428 1/20 0.37
BCL2L1 Q07817 1/20 0.37
CYP2A6 P11509 1/20 0.37
ANPEP P15144 2/20 0.37
IL1RN P18510 1/20 0.37
ERAP2 Q6P179 1/20 0.37
ERAP1 Q9NZ08 1/20 0.37
TDP1 Q9NUW8 1/20 0.35
ESR2 Q92731 1/20 0.34
MEN1 O00255 1/20 0.34
APAF1 O14727 1/20 0.34
NPC1 O15118 1/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1229278 1.00 ALDH1A1 (0.54) ALDH1A1MAPK1BACE1ALOX5CRHBP
Water SCHEMBL2802893 0.98 ALDH1A1 (0.52) ALDH1A1MAPK1BACE1ALOX5CRHBP
SCHEMBL25862086 0.89 ALDH1A1 (0.57) ALDH1A1MAPK1BACE1ALOX5CRHBP
SCHEMBL7523268 0.89 ALDH1A1 (0.54) ALDH1A1MAPK1BACE1ALOX5CRHBP
SCHEMBL66940 0.81 ALDH1A1 (0.50) ALDH1A1MAPK1BACE1ALOX5CRHBP
SCHEMBL1627501 0.80 ALDH1A1 (0.68) ALDH1A1MAPK1BACE1CRHBPCRHR2
SCHEMBL29356458 0.80 ALDH1A1 (0.68) ALDH1A1MAPK1BACE1CRHBPCRHR2
SCHEMBL28358787 0.79 ALDH1A1 (0.48) ALDH1A1MAPK1BACE1ALOX5CRHBP
SCHEMBL31243805 0.79 ALDH1A1 (0.48) ALDH1A1MAPK1BACE1ALOX5CRHBP
SCHEMBL27830861 0.78 ALDH1A1 (0.65) ALDH1A1MAPK1BACE1CRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4451832-A2 HETEROAROMATIC COMPOUNDS Merck Patent GmbH (DE) 2024-10-23 EP disclosed
EP-3728275-B1 HETEROAROMATIC COMPOUNDS MERCK PATENT GMBH (DE) 2024-09-04 EP disclosed
EP-3703722-B1 ADENOVIRUS AND USES THEREOF JANSSEN VACCINES & PREVENTION BV (NL) 2024-06-12 EP disclosed
US-11872281-B2 Adenovirus and uses thereof JANSSEN VACCINES & PREVENTION B.V. (NL) 2024-01-16 US disclosed
EP-3782465-B1 TRANSGENIC ZEBRAFISH MODEL FOR STROKE UNIV POTSDAM (DE) 2023-08-30 EP disclosed