SCHEMBL30567075

SCHEMBL30567075

Cc1nc(C(F)(F)F)ccc1S(=O)(=O)N1CC2(CN(C(=O)C34CCOC(C)(C3)C4)C2)C1

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ TRPV4 Q9HBA0 1/20 0.37
▸ KMT2A Q03164 1/20 0.32
▸ MGLL Q99685 1/20 0.30
▸ PDE2A O00408 1/20 0.30
▸ NAMPT P43490 1/20 0.30
▸ USP9X Q93008 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25370116 1.00 TRPV4 (0.37) TRPV4KMT2AMGLLPDE2ANAMPT
SCHEMBL30567127 0.91 TRPV4 (0.38) TRPV4KMT2APDE2ANAMPT
SCHEMBL25369209 0.91 TRPV4 (0.38) TRPV4KMT2APDE2ANAMPT
SCHEMBL26065201 0.89 KMT2A (0.38) TRPV4KMT2A
SCHEMBL30719552 0.88 TRPV4 (0.39) TRPV4KMT2APDE2A
SCHEMBL27346590 0.88 TRPV4 (0.39) TRPV4KMT2APDE2A
SCHEMBL30719563 0.88 TRPV4 (0.39) TRPV4KMT2APDE2A
SCHEMBL25370981 0.81 TRPV4 (0.38) TRPV4
SCHEMBL30567105 0.81 TRPV4 (0.38) TRPV4
SCHEMBL26065200 0.80 PDE2A (0.32) PDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4482587-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF Biogen MA Inc. (US) 2025-01-01 — — EP disclosed
WO-2023164063-A1 EMOPAMIL-BINDING PROTEIN INHIBITORS AND USES THEREOF BIOGEN MA INC. (US) 2023-08-31 — — WO disclosed
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