Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21831286 | 0.93 | CA1 (0.57) | TSHRL3MBTL1ALDH1A1GAARAB9A | |
| SCHEMBL28002457 | 0.86 | TSHR (0.53) | TSHRL3MBTL1ALDH1A1GAAOPRD1 | |
| SCHEMBL307688 | 0.85 | TSHR (0.56) | TSHRL3MBTL1ALDH1A1GAARAB9A | |
| SCHEMBL3297640 | 0.84 | ALDH1A1 (0.51) | TSHRL3MBTL1ALDH1A1RAB9AMAPT | |
| SCHEMBL13266934 | 0.84 | TSHR (0.64) | TSHRL3MBTL1ALDH1A1GAAOPRD1 | |
| SCHEMBL2484883 | 0.84 | TSHR (0.59) | TSHRL3MBTL1ALDH1A1GAAOPRD1 | |
| SCHEMBL30251598 | 0.84 | TSHR (0.64) | TSHRL3MBTL1ALDH1A1GAAOPRD1 | |
| SCHEMBL2680771 | 0.84 | TSHR (0.64) | TSHRL3MBTL1ALDH1A1GAAOPRD1 | |
| SCHEMBL866718 | 0.84 | TSHR (0.64) | TSHRL3MBTL1ALDH1A1GAAOPRD1 | |
| SCHEMBL16664376 | 0.84 | TSHR (0.59) | TSHRL3MBTL1ALDH1A1GAAOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966166-B1 | 1,2,4-TRIAZOL-l-YL BISPHENYL DERIVATIVES FOR USE IN THE TREATMENT OF ENDOCRINE-DEPENDENT TUMOURS | STERIX LTD (GB) | 2013-01-23 | — | — | EP | disclosed |
| US-8093279-B2 | Compound | STERIX LIMITED (GB) | 2012-01-10 | — | — | US | disclosed |
| US-8022224-B2 | 1,2,4-triazol-1-yl bisphenyl derivatives for use in the treatment of endocrine-dependent tumors | STERIX LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |
| US-20100173963-A1 | COMPOUND | STERIX LIMITED (GB) | 2010-07-08 | — | — | US | disclosed |
| US-20080319037-A1 | 1,2,4-TRIAZOL-1-YL BISPHENYL DERIVATIVES FOR USE IN THE TREATMENT OF ENDOCRINE-DEPENDENT TUMORS | STERIX LIMITED (GB) | 2008-12-25 | — | — | US | disclosed |
| EP-1966166-A1 | 1,2,4-TRIAZOL-l-YL BISPHENYL DERIVATIVES FOR USE IN THE TREATMENT OF ENDOCRINE-DEPENDENT TUMOURS | Sterix Limited (GB) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007068905-A1 | 1,2,4-TRIAZOL-l-YL BISPHENYL DERIVATIVES FOR USE IN THE TREATMENT OF ENDOCRINE-DEPENDENT TUMOURS | STERIX LIMITED (GB) | 2007-06-21 | — | — | WO | disclosed |
| EP-0044119-B1 | PROCESS FOR THE PREPARATION OF COPOLYMERS OF ETHYLENE WITH AT LEAST ONE OTHER 1-ALKENE | STAMICARBON B.V. (NL) | 1985-05-29 | — | — | EP | disclosed |
| EP-0083228-B1 | PHARMACEUTICALLY ACTIVE PHENYLCARBOXYLIC ACID DERIVATIVES | ICI AMERICAS INC. (US) | 1985-05-15 | — | — | EP | disclosed |
| US-4499299-A | Pharmaceutically active phenylcarboxylic acid derivatives | ICI AMERICAS INC. (US) | 1985-02-12 | — | — | US | disclosed |
| US-4435552-A | COORDINATION CATALYST CONTAINING HALOACYL COMPOUND | STAMICARBON B.V. (NL) | 1984-03-06 | — | — | US | disclosed |
| EP-0083228-A1 | Pharmaceutically active phenylcarboxylic acid derivatives | ICI AMERICAS INC. (US) | 1983-07-06 | — | — | EP | disclosed |
| EP-0044119-A2 | Process for the preparation of copolymers of ethylene with at least one other 1-alkene | STAMICARBON B.V. (NL) | 1982-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319037-A1 | 1,2,4-TRIAZOL-1-YL BISPHENYL DERIVATIVES FOR USE IN THE TREATMENT OF ENDOCRINE-DEPENDENT TUMORS | CYP19A1, CYP21A2, CBR1 | TSHR 24/4885L3MBTL1 2427/4885ALDH1A1 625/4885 |
| US-20100173963-A1 | COMPOUND | CBR3, CBR1, OXSR1 | TSHR 179/4885L3MBTL1 1233/4885ALDH1A1 1841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.