Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 11/20 | 0.40 |
| ▸ | CCND1 | P24385 | 9/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 4/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.37 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20425545 | 0.83 | CDK4 (0.45) | CDK4CCND1CDK2CCND3CCND2 | |
| SCHEMBL31438001 | 0.81 | CDK4 (0.40) | OPRM1OPRD1OGFRL1CDK4CCND1 | |
| SCHEMBL31372001 | 0.75 | CDK4 (0.53) | CDK4CCND1CDK2CCND3CCNE1 | |
| SCHEMBL20425411 | 0.75 | CDK4 (0.53) | CDK4CCND1CDK2CCND3CCNE1 | |
| SCHEMBL25090728 | 0.75 | CDK4 (0.47) | CDK4CCND1CDK2CCND3CCNE1 | |
| SCHEMBL25090724 | 0.74 | CDK4 (0.47) | CDK4CCND1CDK2CCND3CCNE1 | |
| SCHEMBL19711678 | 0.73 | CDK4 (0.51) | CDK4CCND1CDK2CCND3CCNE1 | |
| SCHEMBL1988950 | 0.73 | CDK4 (0.52) | CDK4CCND1CDK2CCND3CCNE1 | |
| SCHEMBL4826111 | 0.73 | OPRM1 (0.42) | OPRM1OPRD1OGFRL1CDK4CCND1 | |
| SCHEMBL15238256 | 0.73 | CCR1 (0.37) | CDK4CCND1CDK2STK17BSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12577254-B2 | Thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors | Signal Rx Pharmaceuticals, Inc. | 2026-03-17 | — | — | US | disclosed |
| US-11760762-B2 | Thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors | SIGNALRX PHARMACEUTICALS, INC. (US) | 2023-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11760762-B2 | Thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors | CDK1, CDKN1A, CDKL1 | OPRM1 4259/4885OPRD1 3520/4885OGFRL1 2954/4885 |
| US-12577254-B2 | Thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors | CHEK1, CDK1, CDK3 | OPRM1 2950/4885OPRD1 2419/4885OGFRL1 1415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.