Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 0.45 |
| ▸ | CCND1 | P24385 | 13/20 | 0.45 |
| ▸ | CDK2 | P24941 | 5/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.39 |
| ▸ | CCND3 | P30281 | 10/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | CCND2 | P30279 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30577928 | 0.83 | OPRM1 (0.41) | CDK4CCND1CDK2CCND3CCNE1 | |
| SCHEMBL1991171 | 0.81 | CDK4 (0.50) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL22174830 | 0.78 | CDK4 (0.49) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL4189989 | 0.77 | CCNT1 (0.42) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL19711678 | 0.77 | CDK4 (0.51) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL1988950 | 0.77 | CDK4 (0.52) | CDK4CCND1CDK2CCND3CCNE1 | |
| SCHEMBL20425411 | 0.77 | CDK4 (0.53) | CDK4CCND1CDK2CCND3CCNE1 | |
| SCHEMBL31372001 | 0.77 | CDK4 (0.53) | CDK4CCND1CDK2CCND3CCNE1 | |
| SCHEMBL31475403 | 0.75 | CDK2 (0.57) | CDK4CCND1CDK2CCNA2CCND3 | |
| SCHEMBL22174831 | 0.75 | CDK4 (0.50) | CDK4CCND1CDK2CCND3CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043445-A1 | Thienopyranones and Furanopyranones as Kinase, Bromodomain, and Checkpoint Inhibitors | SIGNALRX PHARMACEUTICALS, INC. (US) | 2024-02-08 | — | — | US | disclosed |
| US-11760762-B2 | Thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors | SIGNALRX PHARMACEUTICALS, INC. (US) | 2023-09-19 | — | — | US | disclosed |
| EP-3573619-A1 | THIENOPYRANONES AND FURANOPYRANONES AS KINASE, BROMODOMAIN, AND CHECKPOINT INHIBITORS | SignalRX Pharmaceuticals, Inc. (US) | 2019-12-04 | — | — | EP | disclosed |
| WO-2018140730-A1 | THIENOPYRANONES AND FURANOPYRANONES AS KINASE, BROMODOMAIN, AND CHECKPOINT INHIBITORS | SIGNALRX PHARMACEUTICALS, INC. (US) | 2018-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11760762-B2 | Thienopyranones and furanopyranones as kinase, bromodomain, and checkpoint inhibitors | CDK1, CDKN1A, CDKL1 | CDK4 8/4885CCND1 11/4885CDK2 4/4885 |
| US-20240043445-A1 | Thienopyranones and Furanopyranones as Kinase, Bromodomain, and Checkpoint Inhibitors | CDK1, CDKN1A, CDKL1 | CDK4 8/4885CCND1 11/4885CDK2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.