Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | KLK1 | P06870 | 1/20 | 0.49 |
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8162830 | 0.85 | SMO (0.50) | KLKB1KLK1SMORAB9AL3MBTL1 | |
| SCHEMBL8186876 | 0.82 | RAB9A (0.66) | KLKB1KLK1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL8181502 | 0.81 | RAB9A (0.67) | KLKB1KLK1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL25156908 | 0.79 | HTR3A (0.44) | KLKB1KLK1SMORAB9AL3MBTL1 | |
| SCHEMBL20807435 | 0.79 | KMT2A (0.61) | RAB9AL3MBTL1ACE2MEN1KMT2A | |
| SCHEMBL12675278 | 0.77 | HTR3A (0.47) | RAB9AL3MBTL1AOC3KMT2A | |
| SCHEMBL11988947 | 0.77 | SMO (0.52) | SMORAB9AL3MBTL1AOC3SMN1; SMN2 | |
| SCHEMBL1431034 | 0.77 | RAB9A (0.67) | RAB9AL3MBTL1SMN1; SMN2KMT2A | |
| SCHEMBL25518000 | 0.77 | HRH4 (0.45) | SMORAB9AL3MBTL1AOC3SMN1; SMN2 | |
| SCHEMBL1331780 | 0.76 | RAB9A (0.64) | KLKB1KLK1RAB9AL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267697-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267697-A1 | ION CHANNEL MODULATORS | CACNA1E, CACNA1A, CACNA1S | KLKB1 2501/4885KLK1 2374/4885SMO 3210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.