Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.51 |
| ▸ | KLK1 | P06870 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1331780 | 0.93 | RAB9A (0.64) | RAB9AMAPK8L3MBTL1KLKB1KLK1 | |
| SCHEMBL8186876 | 0.90 | RAB9A (0.66) | RAB9AL3MBTL1KLKB1KLK1SMN1; SMN2 | |
| SCHEMBL6708288 | 0.86 | RAB9A (0.61) | RAB9AL3MBTL1SMN1; SMN2HTTNPSR1 | |
| SCHEMBL1331001 | 0.84 | RAB9A (0.61) | RAB9AMAPK8L3MBTL1SMN1; SMN2HTT | |
| SCHEMBL1330190 | 0.81 | RAB9A (0.67) | RAB9AMAPK8L3MBTL1SMN1; SMN2HTT | |
| SCHEMBL3057935 | 0.81 | KLKB1 (0.49) | RAB9AL3MBTL1KLKB1KLK1SMN1; SMN2 | |
| SCHEMBL8162830 | 0.79 | SMO (0.50) | RAB9AL3MBTL1KLKB1KLK1SMN1; SMN2 | |
| SCHEMBL2137278 | 0.78 | ALDH1A1 (0.55) | RAB9AL3MBTL1SMN1; SMN2HTTKMT2A | |
| SCHEMBL1331421 | 0.78 | SMN1; SMN2 (0.56) | RAB9AMAPK8SMN1; SMN2HTTKMT2A | |
| SCHEMBL2139557 | 0.77 | ALDH1A1 (0.54) | RAB9AL3MBTL1SMN1; SMN2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |