Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 6/20 | 0.45 |
| ▸ | SRC | P12931 | 6/20 | 0.42 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | ABL2 | P42684 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 7/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 5/20 | 0.38 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26108141 | 1.00 | RIPK2 (0.45) | RIPK2SRCABL1EGFRABL2 | |
| SCHEMBL26108493 | 0.89 | LCK (0.39) | SRCEGFRKDRTEKLCK | |
| SCHEMBL30582551 | 0.89 | LCK (0.39) | SRCEGFRKDRTEKLCK | |
| SCHEMBL30582544 | 0.88 | SRC (0.44) | RIPK2SRCABL1EGFRABL2 | |
| SCHEMBL26108026 | 0.88 | SRC (0.44) | RIPK2SRCABL1EGFRABL2 | |
| SCHEMBL26109460 | 0.87 | RIPK2 (0.43) | RIPK2SRCABL1EGFRABL2 | |
| SCHEMBL26109362 | 0.84 | BTK (0.48) | RIPK2SRCABL1EGFRHCK | |
| SCHEMBL30582530 | 0.84 | BTK (0.48) | RIPK2SRCABL1EGFRHCK | |
| SCHEMBL30582631 | 0.83 | PDE2A (0.43) | RIPK2SRCABL1EGFRKDR | |
| SCHEMBL26108002 | 0.81 | SRC (0.37) | RIPK2SRCABL1EGFRABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4499616-A1 | SPIROBICYCLIC COMPOUNDS | Acerand Therapeutics (Hong Kong) Limited (HK) | 2025-02-05 | — | — | EP | disclosed |
| CN-119013260-A | Spirobicyclic compounds | 优领医药科技(香港)有限公司 | 2024-11-22 | — | — | CN | disclosed |
| WO-2023192502-A1 | SPIROBICYCLIC COMPOUNDS | ACERAND THERAPEUTICS (USA) LIMITED (US) | 2023-10-05 | — | — | WO | disclosed |