Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 7/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18367255 | 1.00 | SLC40A1 (0.41) | SLC40A1HDAC1HDAC6NOTUMRIPK1 | |
| SCHEMBL18367236 | 0.86 | ADORA2A (0.40) | NOTUMRIPK1ADORA2AKLKB1KDM4E | |
| SCHEMBL18367259 | 0.85 | NOTUM (0.46) | SLC40A1NOTUMRIPK1KLKB1KDM4E | |
| SCHEMBL30587508 | 0.85 | NOTUM (0.46) | SLC40A1NOTUMRIPK1KLKB1KDM4E | |
| SCHEMBL18367248 | 0.84 | SLC40A1 (0.42) | SLC40A1HDAC1HDAC6RIPK1HDAC4 | |
| SCHEMBL22736832 | 0.83 | CA5A (0.42) | HDAC1HDAC6NOTUMRIPK1EED | |
| SCHEMBL18366884 | 0.82 | RIPK1 (0.52) | HDAC1HDAC6RIPK1HDAC4HDAC2 | |
| SCHEMBL30587636 | 0.82 | RIPK1 (0.52) | HDAC1HDAC6RIPK1HDAC4HDAC2 | |
| SCHEMBL18366888 | 0.80 | RIPK1 (0.46) | HDAC1HDAC6NOTUMRIPK1HDAC4 | |
| SCHEMBL30092641 | 0.80 | RIPK1 (0.46) | HDAC1HDAC6NOTUMRIPK1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |