Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 9/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | GAA | P10253 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27128736 | 0.82 | RAB9A (0.61) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL24267831 | 0.82 | RAB9A (0.61) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL11304288 | 0.79 | RAB9A (0.69) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL11304285 | 0.79 | RAB9A (0.69) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL31706205 | 0.78 | MAPT (0.53) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL4180835 | 0.75 | RAB9A (1.00) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL4180837 | 0.75 | RAB9A (1.00) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL9735520 | 0.75 | RAB9A (0.58) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL5051613 | 0.74 | PAX8 (0.65) | SMN1; SMN2RAB9ANPC1GAALMNA | |
| SCHEMBL7522459 | 0.74 | RAB9A (0.76) | SMN1; SMN2RAB9ANPC1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |