Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 11/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3056696 | 0.90 | CASP3 (0.55) | CASP3SENP8SENP7SENP6KMT2A | |
| SCHEMBL2682508 | 0.81 | CASP3 (0.54) | CASP3SENP8SENP7SENP6KMT2A | |
| SCHEMBL3057661 | 0.80 | KMT2A (0.58) | KMT2ATP53ALOX15MAPK1MEN1 | |
| SCHEMBL3060581 | 0.79 | KMT2A (0.49) | KMT2ATP53ALOX15MAPK1MEN1 | |
| SCHEMBL14817330 | 0.77 | CASP3 (0.37) | CASP3SENP8SENP7SENP6KMT2A | |
| SCHEMBL3042819 | 0.76 | KMT2A (0.44) | KMT2ATP53ALOX15MAPK1MEN1 | |
| SCHEMBL14817328 | 0.76 | KMT2A (0.38) | KMT2ATP53ALOX15MAPK1MEN1 | |
| SCHEMBL2683121 | 0.75 | CASP3 (0.47) | CASP3SENP8SENP7SENP6TP53 | |
| SCHEMBL3053709 | 0.73 | KMT2A (0.41) | KMT2ATP53ALOX15MAPK1MEN1 | |
| SCHEMBL14817329 | 0.73 | KMT2A (0.36) | KMT2ATP53ALOX15MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492428-B2 | Small-molecule botulinum toxin inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-07-23 | — | — | US | disclosed |
| US-20100260778-A1 | SMALL-MOLECULE BOTULINUM TOXIN INHIBITORS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100260778-A1 | SMALL-MOLECULE BOTULINUM TOXIN INHIBITORS | BTD, RAC2, BTN3A1 | CASP3 2737/4885SENP8 2848/4885SENP7 3021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.