Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3042819 | 0.84 | KMT2A (0.44) | KMT2AMAPK1TP53ALOX15ALDH1A1 | |
| SCHEMBL3057661 | 0.79 | KMT2A (0.58) | KMT2AMAPK1TP53ALOX15ALDH1A1 | |
| SCHEMBL3060581 | 0.78 | KMT2A (0.49) | KMT2AMAPK1TP53ALOX15ALDH1A1 | |
| SCHEMBL3058707 | 0.76 | MAPT (0.40) | KMT2AMAPK1TP53ALOX15ALDH1A1 | |
| SCHEMBL3058848 | 0.73 | CASP3 (0.51) | KMT2AMAPK1TP53ALOX15ALDH1A1 | |
| SCHEMBL2683619 | 0.73 | PARP1 (0.43) | KMT2AMAPK1PARP1ALDH1A1MAPT | |
| SCHEMBL3058700 | 0.70 | MAPT (0.56) | KMT2AMAPK1TP53ALOX15ALDH1A1 | |
| SCHEMBL6561918 | 0.70 | VCAM1 (0.68) | MAPK1PARP1ALDH1A1MAPTCDC25B | |
| SCHEMBL14817328 | 0.70 | KMT2A (0.38) | KMT2AMAPK1TP53ALOX15ALDH1A1 | |
| SCHEMBL2683137 | 0.69 | PARP1 (0.42) | KMT2AMAPK1TP53PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492428-B2 | Small-molecule botulinum toxin inhibitors | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-07-23 | — | — | US | disclosed |
| US-20100260778-A1 | SMALL-MOLECULE BOTULINUM TOXIN INHIBITORS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2010-10-14 | — | — | US | disclosed |
| WO-2008051197-A2 | SMALL-MOLECULE BOTULINUM TOXIN INHIBITORS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100260778-A1 | SMALL-MOLECULE BOTULINUM TOXIN INHIBITORS | BTD, RAC2, BTN3A1 | KMT2A 3518/4885MAPK1 1965/4885TP53 4436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.