Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ADCY10 | Q96PN6 | 11/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26127106 | 1.00 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1KDM4EADCY10SMN1; SMN2 | |
| SCHEMBL22501986 | 0.80 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1KDM4EADCY10KMT2A | |
| Hydrochloric Acid SCHEMBL22502036 | 0.78 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1KDM4EADCY10KMT2A | |
| SCHEMBL4282276 | 0.75 | HSP90AB1 (0.60) | HSP90AA1HSP90AB1KDM4EADCY10SMN1; SMN2 | |
| SCHEMBL3951313 | 0.74 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1KDM4EADCY10 | |
| SCHEMBL22502009 | 0.74 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1KDM4EADCY10KMT2A | |
| SCHEMBL4211927 | 0.74 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1KDM4EADCY10 | |
| SCHEMBL28043877 | 0.73 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1KDM4EADCY10 | |
| SCHEMBL14413009 | 0.72 | HSP90AB1 (0.62) | HSP90AA1HSP90AB1KDM4EADCY10SMN1; SMN2 | |
| SCHEMBL24298821 | 0.72 | ADCY10 (0.50) | HSP90AA1HSP90AB1KDM4EADCY10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4504739-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2025-02-12 | — | — | EP | disclosed |
| WO-2023196429-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-12 | — | — | WO | disclosed |