Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TKT | P29401 | 1/20 | 0.52 |
| ▸ | AOC1 | P19801 | 2/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979284 | 0.83 | AOC1 (0.61) | TKTAOC1AOC3GAAKDM4E | |
| SCHEMBL1930789 | 0.83 | — | — | |
| SCHEMBL29964442 | 0.83 | — | — | |
| SCHEMBL16307598 | 0.79 | AOC1 (0.50) | TKTAOC1AOC3GAAKDM4E | |
| SCHEMBL15390035 | 0.79 | AOC1 (0.50) | TKTAOC1AOC3GAAKDM4E | |
| SCHEMBL18716208 | 0.79 | CYP2E1 (0.47) | TKTAOC1AOC3GAAKDM4C | |
| Hydrochloric Acid SCHEMBL28577547 | 0.78 | AOC1 (0.42) | TKTAOC1AOC3LOXL2SCN9A | |
| SCHEMBL27644996 | 0.76 | AOC1 (0.42) | TKTAOC1AOC3GAATDP1 | |
| SCHEMBL31620775 | 0.76 | — | — | |
| SCHEMBL18228602 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2850044-A2 | USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING | The University of Chicago (US) | 2015-03-25 | — | — | EP | claimed |
| WO-2013173746-A2 | USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING | THE UNIVERSITY OF CHICAGO (US) | 2013-11-21 | — | — | WO | claimed |
| US-20210017133-A1 | USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING | THE UNIVERSITY OF CHICAGO | 2021-01-21 | — | — | US | disclosed |
| US-20210017133-A1 | USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING | THE UNIVERSITY OF CHICAGO | 2021-01-21 | — | — | US | disclosed |
| US-10442767-B2 | Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging | THE UNIVERSITY OF CHICAGO (US) | 2019-10-15 | — | — | US | disclosed |
| US-10442767-B2 | Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging | THE UNIVERSITY OF CHICAGO (US) | 2019-10-15 | — | — | US | disclosed |
| US-20170174629-A1 | USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING | THE UNIVERSITY OF CHICAGO | 2017-06-22 | — | — | US | disclosed |
| US-20170174629-A1 | USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING | THE UNIVERSITY OF CHICAGO | 2017-06-22 | — | — | US | disclosed |
| US-20170174629-A1 | USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING | THE UNIVERSITY OF CHICAGO | 2017-06-22 | — | — | US | disclosed |
| EP-2850044-B1 | USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING | UNIV CHICAGO (US) | 2017-05-17 | — | — | EP | disclosed |
| US-9617215-B2 | Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging | THE UNIVERSITY OF CHICAGO (US) | 2017-04-11 | — | — | US | disclosed |
| US-20100261707-A9 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2010-10-14 | — | — | US | disclosed |
| US-20090233911-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-09-17 | — | — | US | disclosed |
| US-20090054410-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | NV REMYND (BE) | 2009-02-26 | — | — | US | disclosed |
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
| CN-1780821-A | Heterocyclic kinase inhibitors. | ABBOTT LAB (US) | 2006-05-31 | — | — | CN | disclosed |
| EP-1606268-A1 | HETEROCYCLIC KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-21 | — | — | EP | disclosed |
| US-20040254159-A1 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES | 2004-12-16 | — | — | US | disclosed |
| WO-2004076424-A1 | HETEROCYCLIC KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210017133-A1 | USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING | KCNQ4, KCNJ4, KCNQ2 | TKT 2342/4885AOC1 2811/4885AOC3 3607/4885 |
| US-20170174629-A1 | USE OF FLUORINATED DERIVATIVES OF 4-AMINOPYRIDINE IN THERAPEUTICS AND MEDICAL IMAGING | KCNQ4, KCNJ4, KCNQ2 | TKT 2342/4885AOC1 2811/4885AOC3 3607/4885 |
| US-20090233911-A2 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | TKT 519/4885AOC1 3905/4885AOC3 607/4885 |
| US-20040254159-A1 | Heterocyclic kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | TKT 501/4885AOC1 2967/4885AOC3 3772/4885 |
| US-10442767-B2 | Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging | KCNJ4, KCNQ4, KCNQ2 | TKT 2279/4885AOC1 3230/4885AOC3 3693/4885 |
| US-20100261707-A9 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | TKT 519/4885AOC1 3905/4885AOC3 607/4885 |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | TKT 511/4885AOC1 2871/4885AOC3 3808/4885 |
| US-20090054410-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, HTT, PARK7 | TKT 519/4885AOC1 3905/4885AOC3 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.