Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26105711 | 0.92 | TRPV1 (0.55) | TRPV1TRPA1MAPTGPR119PDE10A | |
| SCHEMBL30592034 | 0.92 | TRPV1 (0.55) | TRPV1TRPA1MAPTGPR119PDE10A | |
| SCHEMBL1875507 | 0.89 | ALDH1A1 (0.51) | TRPV1TRPA1MAPTGPR119PDE10A | |
| SCHEMBL30591902 | 0.84 | GRIA1 (0.53) | TRPV1TRPA1MAPTGPR119HPGD | |
| SCHEMBL26105834 | 0.84 | GRIA1 (0.53) | TRPV1TRPA1MAPTGPR119HPGD | |
| SCHEMBL30591874 | 0.82 | TRPV1 (0.52) | TRPV1TRPA1MAPTPDE10ASMN1; SMN2 | |
| SCHEMBL26106492 | 0.82 | GPR119 (0.50) | TRPV1TRPA1MAPTGPR119PDE10A | |
| SCHEMBL30591969 | 0.82 | GPR119 (0.50) | TRPV1TRPA1MAPTGPR119PDE10A | |
| SCHEMBL30591699 | 0.81 | MAPT (0.56) | TRPV1TRPA1MAPTGPR119SMN1; SMN2 | |
| SCHEMBL26103659 | 0.81 | MAPT (0.56) | TRPV1TRPA1MAPTGPR119SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250206722-A1 | SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS | THE SCRIPPS RESEARCH INSTITUTE | 2025-06-26 | — | — | US | disclosed |
| CN-119403551-A | Small molecule inhibitors of TEA domain family members | 斯克里普斯研究学院 | 2025-02-07 | — | — | CN | disclosed |
| EP-4496570-A2 | SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS | The Scripps Research Institute (US) | 2025-01-29 | — | — | EP | disclosed |
| WO-2023183768-A2 | SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206722-A1 | SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS | YAP1, TEAD1, TEAD2 | TRPV1 3566/4885TRPA1 3692/4885MAPT 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.