Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.32 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30592225 | 0.73 | DPP4 (0.38) | DPP8DPP9DPP7DPP4 | |
| SCHEMBL30592083 | 0.71 | DPP4 (0.37) | KCNH2DPP8DPP9DPP7DPP4 | |
| SCHEMBL30592331 | 0.70 | CHRNB2 (0.32) | DPP4 | |
| SCHEMBL24819773 | 0.69 | KCNH2 (0.39) | GPR139KCNH2SCN5AIRAK4 | |
| SCHEMBL30592208 | 0.69 | L3MBTL1 (0.40) | LMNADPP8DPP9DPP7DPP4 | |
| SCHEMBL24820619 | 0.69 | KCNH2 (0.38) | GPR139KCNH2SCN5AIRAK4 | |
| SCHEMBL8383259 | 0.63 | GPR139 (0.40) | GPR139PTGS1PTGS2 | |
| SCHEMBL21477243 | 0.63 | CRBN (0.51) | — | |
| SCHEMBL30918644 | 0.60 | HDAC2 (0.61) | DPP4 | |
| SCHEMBL29062785 | 0.60 | HDAC2 (0.61) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3472149-B1 | HETEROCYCLIC PROLINAMIDE DERIVATIVES | Orion Ophthalmology LLC (US) | 2023-08-30 | — | — | EP | claimed |