Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 1/20 | 0.49 |
| ▸ | PRKCA | P17252 | 8/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | PRKCH | P24723 | 1/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | CDC25B | P30305 | 2/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 3/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22710203 | 0.75 | BCHE (0.45) | TACR2TSHR | |
| SCHEMBL18080649 | 0.73 | PDPK1 (0.44) | TACR2ALDH1A1TSHR | |
| SCHEMBL7774705 | 0.70 | PTPN1 (0.45) | HPSEPTPN1CDC25BMEN1KMT2A | |
| SCHEMBL6296951 | 0.69 | TACR2 (0.45) | HPSEPTPN1TACR2ALDH1A1CYP3A4 | |
| SCHEMBL21679664 | 0.69 | POLB (0.52) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| SCHEMBL21679680 | 0.69 | POLB (0.52) | PRKCAPRKD3PRKCGPRKCBPRKCH | |
| SCHEMBL18456611 | 0.68 | NAAA (0.46) | TACR2ALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL18456612 | 0.68 | NAAA (0.46) | TACR2ALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL20741887 | 0.68 | SLC6A2 (0.46) | TACR2ALDH1A1TSHR | |
| SCHEMBL1821071 | 0.68 | CES2 (0.46) | HPSEPTPN1CETPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250204515-A1 | Heparanase Inhibition for Graft Protection | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2025-06-26 | — | — | US | claimed |
| WO-2023175581-A1 | HEPARANASE INHIBITION FOR GRAFT PROTECTION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2023-09-21 | — | — | WO | claimed |
| US-20250204515-A1 | Heparanase Inhibition for Graft Protection | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2025-06-26 | — | — | US | disclosed |
| WO-2023175581-A1 | HEPARANASE INHIBITION FOR GRAFT PROTECTION | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2023-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250204515-A1 | Heparanase Inhibition for Graft Protection | HPSE, ENGASE, HPN | HPSE 1/4885PRKCA 3985/4885PRKD3 4545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.