Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25151518 | 1.00 | GAA (0.53) | GAAPOLBMAOBKMT2ACASP3 | |
| SCHEMBL26608385 | 0.87 | MTNR1A (0.46) | GAAPOLBMAOBKMT2ACASP3 | |
| SCHEMBL26601614 | 0.87 | POLB (0.49) | GAAPOLBMAOBKMT2ACASP3 | |
| SCHEMBL26601686 | 0.87 | RAB9A (0.50) | GAAKMT2AMAPTALDH1A1HPGD | |
| SCHEMBL31336208 | 0.87 | RAB9A (0.50) | GAAKMT2AMAPTALDH1A1HPGD | |
| SCHEMBL26601891 | 0.86 | NPSR1 (0.43) | GAAPOLBMAOBKMT2ACASP3 | |
| SCHEMBL24772939 | 0.81 | GAA (0.53) | GAAPOLBMAPTALDH1A1HPGD | |
| SCHEMBL14966627 | 0.80 | MAOB (0.48) | GAAPOLBMAOBMAPTPTPN11 | |
| SCHEMBL30887705 | 0.79 | GAA (0.52) | GAAPOLBKMT2ACASP3SENP8 | |
| SCHEMBL31747868 | 0.78 | GAA (0.44) | GAAPOLBMAOBKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4511115-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | Vertex Pharmaceuticals Incorporated (US) | 2025-02-26 | — | — | EP | disclosed |
| WO-2023205468-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |