Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.77 |
| ▸ | NPC1 | O15118 | 3/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | CASP3 | P42574 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.63 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.63 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10144000 | 0.95 | ALDH1A1 (0.71) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3062637 | 0.89 | SMN1; SMN2 (0.69) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3039371 | 0.88 | ALDH1A1 (0.63) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL24769827 | 0.87 | RAB9A (0.74) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4250684 | 0.87 | NPC1 (1.00) | RAB9ANPC1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3046207 | 0.87 | SMN1; SMN2 (0.84) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1337740 | 0.86 | ALDH1A1 (0.67) | RAB9ANPC1ALDH1A1SMN1; SMN2ALOX12 | |
| SCHEMBL1336791 | 0.86 | KCNK3 (0.73) | RAB9ANPC1ALDH1A1SMN1; SMN2ALOX12 | |
| SCHEMBL3056608 | 0.86 | SMN1; SMN2 (0.65) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3049631 | 0.84 | SMN1; SMN2 (0.79) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200977-B1 | F1F0-ATPASE INHIBITORS AND RELATED METHODS | UNIV MICHIGAN (US) | 2016-11-09 | — | — | EP | disclosed |
| US-8324258-B2 | F1F0-ATPase inhibitors and related methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-12-04 | — | — | US | disclosed |
| US-20100222400-A1 | F1F0-ATPase Inhibitors and Related Methods | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222400-A1 | F1F0-ATPase Inhibitors and Related Methods | ATP5F1A, ATP5F1B, ATP5F1D | RAB9A 855/4885NPC1 1071/4885ALDH1A1 2038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.