Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | GLP1R | P43220 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATF1 | P18846 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | XPO1 | O14980 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22193255 | 0.78 | NCF1 (0.38) | CYP1A2CYP3A4ALOX15TSHRMAPK1 | |
| SCHEMBL25332545 | 0.77 | CYP1A2 (0.37) | CYP1A2CYP3A4ALOX15TSHRMAPK1 | |
| SCHEMBL30469075 | 0.77 | CYP1A2 (0.37) | CYP1A2CYP3A4ALOX15TSHRMAPK1 | |
| SCHEMBL28547213 | 0.75 | XPO1 (0.37) | HSD17B10ATF1NFKB1XPO1ACACB | |
| SCHEMBL21725543 | 0.74 | AR (0.40) | NOTUMCYP1A2CYP3A4ALOX15TSHR | |
| SCHEMBL21246705 | 0.74 | NCF1 (0.41) | CYP1A2CYP3A4ALOX15TSHRMAPK1 | |
| SCHEMBL13865699 | 0.74 | NOTUM (0.37) | NOTUMCYP1A2GLP1RKDM4EXBP1 | |
| SCHEMBL10748633 | 0.73 | XPO1 (0.41) | NOTUMCYP3A4TSHRTDP1GLP1R | |
| SCHEMBL23762526 | 0.71 | GABRA2 (0.35) | NOTUMTDP1ARGAAGLP1R | |
| SCHEMBL21725545 | 0.70 | CRHR1 (0.37) | CYP1A2CYP3A4ALOX15TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116829546-A | Novel heteroaryl substituted imidazole derivatives | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |