Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28365698 | 1.00 | TRPV1 (0.51) | TRPV1NAMPTCDK5CCNE1CDK2 | |
| SCHEMBL3246360 | 0.89 | TRPV1 (0.63) | TRPV1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2396852 | 0.83 | ALDH1A1 (0.63) | ALDH1A1HPGD | |
| SCHEMBL30601010 | 0.82 | MAP4K1 (0.44) | TRPV1NAMPT | |
| SCHEMBL30645377 | 0.80 | MEN1 (0.53) | TRPV1CDK5CCNE1CDK2ALDH1A1 | |
| SCHEMBL9651248 | 0.80 | MEN1 (0.53) | TRPV1CDK5CCNE1CDK2ALDH1A1 | |
| SCHEMBL30600809 | 0.80 | MAP4K1 (0.43) | NAMPTCDK5 | |
| SCHEMBL18522430 | 0.78 | NAMPT (0.50) | NAMPT | |
| SCHEMBL30600745 | 0.78 | TRPV1 (0.52) | TRPV1CDK5CCNE1CDK2ALDH1A1 | |
| SCHEMBL28361832 | 0.78 | TRPV1 (0.48) | TRPV1CDK5CCNE1CDK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117024411-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2026-05-19 | — | — | CN | disclosed |
| CN-110709392-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |