Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9185598 | 1.00 | ALDH1A1 (0.42) | ALDH1A1CES2CES1EPHX1HIF1A | |
| Acetic Acid SCHEMBL8651424 | 0.89 | ALDH1A1 (0.39) | ALDH1A1CES2CES1EPHX1HIF1A | |
| Carbamic Acid SCHEMBL7606250 | 0.89 | EPHX1 (0.41) | ALDH1A1CES2CES1EPHX1HIF1A | |
| SCHEMBL18687242 | 0.84 | EPHX1 (0.50) | ALDH1A1CES2CES1EPHX1HIF1A | |
| SCHEMBL19275031 | 0.84 | EPHX1 (0.50) | ALDH1A1CES2CES1EPHX1HIF1A | |
| SCHEMBL215604 | 0.84 | EPHX1 (0.50) | ALDH1A1CES2CES1EPHX1HIF1A | |
| SCHEMBL19402802 | 0.84 | EPHX1 (0.50) | ALDH1A1CES2CES1EPHX1HIF1A | |
| SCHEMBL6676680 | 0.84 | EPHX1 (0.50) | ALDH1A1CES2CES1EPHX1HIF1A | |
| SCHEMBL19387381 | 0.84 | EPHX1 (0.50) | ALDH1A1CES2CES1EPHX1HIF1A | |
| SCHEMBL20887677 | 0.84 | EPHX1 (0.50) | ALDH1A1CES2CES1EPHX1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10247712-B2 | Printable oxygen sensing composition | SUN CHEMICAL B.V. (NL) | 2019-04-02 | — | — | US | disclosed |
| US-20170016865-A1 | PRINTABLE OXYGEN SENSING COMPOSITION | SUN CHEMICAL B.V. (NL) | 2017-01-19 | — | — | US | disclosed |
| US-9459241-B2 | Printable oxygen sensing composition | SUN CHEMICAL B.V. (NL) | 2016-10-04 | — | — | US | disclosed |
| EP-2195649-B1 | Printable oxygen sensing composition and a substrate or pouch coated with the composition | SUN CHEMICAL BV (NL) | 2015-11-18 | — | — | EP | disclosed |
| US-20100221468-A1 | PRINTABLE OXYGEN SENSING COMPOSITION | SUN CHEMICAL B.V. | 2010-09-02 | — | — | US | disclosed |
| EP-2195649-A1 | PRINTABLE OXYGEN SENSING COMPOSITION | Sun Chemical B.V. (NL) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009037477-A1 | PRINTABLE OXYGEN SENSING COMPOSITION | SUN CHEMICAL LIMITED (GB) | 2009-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170016865-A1 | PRINTABLE OXYGEN SENSING COMPOSITION | COXFA4L2, PPOX, PDE6B | ALDH1A1 764/4885CES2 2216/4885CES1 4279/4885 |
| US-10247712-B2 | Printable oxygen sensing composition | COXFA4L2, PPOX, PDE6B | ALDH1A1 764/4885CES2 2216/4885CES1 4279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.