Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | SLC6A15 | Q9H2J7 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 7/20 | 0.35 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 5/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18081229 | 0.82 | PDK4 (0.51) | JAK1BTKCNR1 | |
| SCHEMBL29910537 | 0.82 | PDK4 (0.51) | JAK1BTKCNR1 | |
| SCHEMBL18081230 | 0.81 | QDPR (0.46) | BTKCNR1 | |
| SCHEMBL28565843 | 0.80 | CNR1 (0.37) | SMN1; SMN2LMNAJAK1BTKCNR1 | |
| SCHEMBL18038844 | 0.77 | PDK4 (0.46) | JAK1BTKCNR1 | |
| SCHEMBL29948559 | 0.77 | CNR1 (0.50) | SMN1; SMN2LMNAPOLBCNR1 | |
| SCHEMBL29650110 | 0.77 | LMNA (0.47) | SMN1; SMN2LMNAPOLBCNR1NPC1 | |
| SCHEMBL29684579 | 0.76 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAPOLBBTKOPRD1 | |
| SCHEMBL30180149 | 0.76 | QDPR (0.37) | SMN1; SMN2LMNAPOLBJAK1JAK2 | |
| SCHEMBL31329758 | 0.75 | PTGDR2 (0.38) | SMN1; SMN2LMNAPOLBJAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262036-B1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2023-09-13 | — | — | EP | disclosed |