SCHEMBL30607647

SCHEMBL30607647

COc1ccc(-c2ncccc2C#N)cn1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.53
TRPV1 Q8NER1 1/20 0.42
HSD17B1 P14061 1/20 0.41
HSD17B2 P37059 1/20 0.41
CYP2A6 P11509 2/20 0.41
TGFBR1 P36897 1/20 0.41
CYP19A1 P11511 2/20 0.40
HDAC1 Q13547 1/20 0.40
AVPR2 P30518 1/20 0.39
OXTR P30559 1/20 0.39
AVPR1A P37288 1/20 0.39
MKNK1 Q9BUB5 1/20 0.39
MKNK2 Q9HBH9 1/20 0.39
ALDH1A1 P00352 2/20 0.39
MAPT P10636 1/20 0.39
PDE4B Q07343 1/20 0.38
NAAA Q02083 1/20 0.38
KDM4E B2RXH2 1/20 0.38
HPGD P15428 1/20 0.38
PIK3CA P42336 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30607566 0.82 CNR2 (0.50) CNR2TRPV1HDAC1PDE4BPIK3CA
SCHEMBL16879478 0.80 ALDH1A1 (0.59) CNR2TRPV1HDAC1ALDH1A1MAPT
SCHEMBL31264203 0.79 AVPR2 (0.55) HSD17B1HSD17B2CYP2A6AVPR2OXTR
SCHEMBL10094701 0.78 CYP2A6 (0.57) CNR2TRPV1HSD17B1HSD17B2CYP2A6
SCHEMBL30482533 0.77 HSD17B1 (0.44) HSD17B1HSD17B2CYP2A6CYP19A1MKNK1
SCHEMBL3292911 0.77 CNR2 (0.57) CNR2TRPV1CYP2A6TGFBR1HDAC1
SCHEMBL30607721 0.77 CNR2 (0.53) CNR2TRPV1HDAC1ALDH1A1MAPT
SCHEMBL10094474 0.75 HSD17B1 (0.42) HSD17B1HSD17B2CYP2A6CYP19A1MKNK1
SCHEMBL30332369 0.74 CYP2A6 (0.56) CNR2CYP2A6ALDH1A1MAPTKDM4E
SCHEMBL3237463 0.74 CYP2A6 (0.56) CNR2CYP2A6ALDH1A1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023186065-A1 A CYCLIN-DEPENDENT KINASE INHIBITOR Taizhou Eoc Pharma Co., Ltd. (CN) 2023-10-05 WO disclosed