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SCHEMBL30608583

SCHEMBL30608583

NC(=O)CC[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CXCL8 P10145 7/20 0.54
▸ OPRM1 P35372 3/20 0.52
▸ OPRD1 P41143 2/20 0.52
▸ CCKBR P32239 1/20 0.51
▸ GNRHR P30968 1/20 0.50
▸ GLP1R P43220 5/20 0.50
▸ GIPR P48546 5/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30608573 0.91 CXCL8 (0.54) CXCL8CCKBR
SCHEMBL30608621 0.90 CAPN1 (0.50) CXCL8GLP1RGIPR
SCHEMBL30608611 0.90 CAPN1 (0.50) CXCL8GLP1RGIPR
SCHEMBL30608600 0.88 CAPN1 (0.51) GNRHRGLP1RGIPR
SCHEMBL30398216 0.88 CXCR4 (0.49) CXCL8OPRM1OPRD1CCKBR
SCHEMBL30608597 0.88 GRPR (0.48) CXCL8GLP1RGIPR
SCHEMBL30608565 0.86 CAPN1 (0.59) CXCL8GLP1RGIPR
SCHEMBL30608566 0.86 CAPN1 (0.59) CXCL8GLP1RGIPR
SCHEMBL30608620 0.86 OPRM1 (0.53) CXCL8OPRM1OPRD1
SCHEMBL30608610 0.86 CXCL8 (0.54) CXCL8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4646232-A1 VARIANT LIGAND CONJUGATES FOR PAYLOAD DELIVERY Université de Genève (CH) 2025-11-12 — — EP claimed
WO-2024146707-A1 VARIANT LIGAND CONJUGATES FOR PAYLOAD DELIVERY UNIVERSITÉ DE GENÈVE (CH) 2024-07-11 — — WO claimed
EP-4646232-A1 VARIANT LIGAND CONJUGATES FOR PAYLOAD DELIVERY Université de Genève (CH) 2025-11-12 — — EP disclosed
US-20250090637-A1 METHODS OF INHIBITING CEREBRAL INFLAMMATION UNIVERSITÉ DE GENÈVE (CH) 2025-03-20 — — US disclosed
CN-112469429-B Use of CCR5 inhibitors in cancer treatment 奥立安生物技术瑞士有限责任公司 2025-02-14 — — CN disclosed
CN-112469430-B Method for inhibiting cerebral inflammation 日内瓦大学 2024-12-24 — — CN disclosed
WO-2024146707-A1 VARIANT LIGAND CONJUGATES FOR PAYLOAD DELIVERY UNIVERSITÉ DE GENÈVE (CH) 2024-07-11 — — WO disclosed
EP-3813870-B1 CCR5 INHIBITOR FOR USE IN TREATING CANCER ORION Biotechnology Switzerland Sarl (CH) 2023-11-15 — — EP disclosed
EP-3813869-B1 CCR5 INHIBITOR FOR USE IN TREATING A NEUROINFLAMMATORY DISORDER THAT INVOLVES CEREBRAL INFLAMMATION UNIV GENEVE (CH) 2023-10-18 — — EP disclosed
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