Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.33 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30612659 | 1.00 | BRD4 (0.35) | BRD4KDM4EALDH1A1BRPF1SMN1; SMN2 | |
| SCHEMBL30647145 | 0.75 | BRD4 (0.35) | BRD4KDM4EALDH1A1BRPF1SMN1; SMN2 | |
| SCHEMBL29092183 | 0.75 | BRD4 (0.35) | BRD4KDM4EALDH1A1BRPF1SMN1; SMN2 | |
| SCHEMBL30647220 | 0.75 | BRD4 (0.35) | BRD4KDM4EALDH1A1BRPF1SMN1; SMN2 | |
| SCHEMBL709323 | 0.70 | BRD4 (0.47) | BRD4KDM4EALDH1A1BRPF1SMN1; SMN2 | |
| SCHEMBL28300808 | 0.70 | BRD4 (0.47) | BRD4KDM4EALDH1A1BRPF1SMN1; SMN2 | |
| SCHEMBL924794 | 0.67 | USP2 (0.40) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL23805183 | 0.66 | KDM4E (0.42) | BRD4KDM4EALDH1A1BRPF1SMN1; SMN2 | |
| SCHEMBL28251574 | 0.66 | PARP10 (0.42) | BRD4KDM4EALDH1A1BRPF1SMN1; SMN2 | |
| SCHEMBL30601124 | 0.65 | CHRNB2 (0.35) | KDM4EALDH1A1PARP10OPRK1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348424-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | SCHRÖDINGER, INC. | 2023-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348424-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | APC, RCC2, CDC37 | BRD4 1287/4885KDM4E 4187/4885ALDH1A1 2243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.