Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.32 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30647220 | 1.00 | BRD4 (0.35) | BRD4BRD9MAPK1MEN1KMT2A | |
| SCHEMBL29092183 | 1.00 | BRD4 (0.35) | BRD4BRD9MAPK1MEN1KMT2A | |
| SCHEMBL30612666 | 0.75 | BRD4 (0.35) | BRD4BRD9PARP1PARP15PARP10 | |
| SCHEMBL30612659 | 0.75 | BRD4 (0.35) | BRD4BRD9PARP1PARP15PARP10 | |
| SCHEMBL29092378 | 0.72 | PARP1 (0.40) | BRD4KMT2APARP1PARP2CNR2 | |
| SCHEMBL18584635 | 0.72 | BRD4 (0.49) | BRD4BRD9MAPK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL18584529 | 0.70 | BRD4 (0.47) | BRD4BRD9MAPK1MEN1KMT2A | |
| SCHEMBL30647042 | 0.68 | BRD4 (0.36) | BRD4BRD9ALDH1A1BRPF1 | |
| SCHEMBL29092754 | 0.66 | BRD4 (0.40) | BRD4BRD9MAPK1PARP1PARP15 | |
| SCHEMBL24573834 | 0.62 | KMT2A (0.38) | KMT2ACNR2KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137542-B | Pyridone dicarboxamides as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2023-10-27 | — | — | CN | disclosed |