Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.46 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.46 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.46 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26135858 | 0.81 | NPC1 (0.63) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL26584249 | 0.79 | LMNA (0.49) | NPC1RAB9AALDH1A1LMNATTR | |
| SCHEMBL10783189 | 0.75 | CA12 (0.59) | NPC1RAB9ACCNCCDK8HSD17B1 | |
| SCHEMBL3414116 | 0.75 | CA12 (0.50) | NPC1RAB9AP2RY12MAPTKDM4E | |
| SCHEMBL11218812 | 0.74 | CA12 (0.54) | NPC1RAB9ACCNCCDK8HSD17B1 | |
| SCHEMBL6853096 | 0.74 | CA12 (0.54) | NPC1RAB9ACCNCCDK8HSD17B1 | |
| SCHEMBL11054639 | 0.74 | CA12 (0.57) | NPC1RAB9ACCNCCDK8HSD17B1 | |
| SCHEMBL2540882 | 0.74 | HSD17B1 (0.67) | CCNCCDK8HSD17B1HSD17B2MAPT | |
| SCHEMBL9736693 | 0.73 | KDM4E (0.48) | NPC1RAB9AP2RY12MAPTKDM4E | |
| SCHEMBL9736700 | 0.73 | KDM4E (0.48) | NPC1RAB9AP2RY12MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023194895-A1 | PYRROL DERIVATIVES AS INHIBITORS OF APOLIPOPROTEIN L-1 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-10-12 | — | — | WO | disclosed |