Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16301663 | 0.81 | HTT (0.34) | HTTKDM4EALDH1A1 | |
| SCHEMBL2454342 | 0.77 | HTT (0.38) | HTT | |
| SCHEMBL15547333 | 0.76 | HTT (0.36) | HTTKDM4EALDH1A1 | |
| SCHEMBL15547941 | 0.73 | TYR (0.40) | KDM4EALDH1A1 | |
| SCHEMBL12788253 | 0.71 | SRC (0.38) | — | |
| SCHEMBL14734455 | 0.70 | MEN1 (0.34) | KDM4EALDH1A1 | |
| SCHEMBL9621372 | 0.70 | KDM4E (0.32) | KDM4EALDH1A1 | |
| SCHEMBL8020079 | 0.70 | MAPK1 (0.34) | HTTKDM4EALDH1A1 | |
| SCHEMBL10393962 | 0.70 | MAPK1 (0.34) | HTT | |
| SCHEMBL30689650 | 0.70 | MAPK1 (0.34) | HTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014012593-A1 | ALKYL SUBSTITUTED 3-HYDROXYPYRIDINES FOR THE TREATMENT OF DEPRESSION | HandelsOrt AG (CH) | 2014-01-23 | — | — | WO | claimed |
| EP-2231603-B1 | SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | BIRYUKOV DMITRI VALERIEVICH (RU) | 2013-05-01 | — | — | EP | claimed |
| US-20120270908-A1 | SUBSTITUTED 3 -HYDROZYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | BIRYUKOV DMITRI VALERIEVICH (RU) | 2012-10-25 | — | — | US | claimed |
| US-20100261764-A1 | SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | BIRYUKOV DMITRI VALERIEVICH | 2010-10-14 | — | — | US | claimed |
| EP-2231603-A1 | SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | Biryukov, Dmitri Valerievich (RU) | 2010-09-29 | — | — | EP | claimed |
| WO-2009078746-A1 | SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | BIRYUKOV DMITRI VALERIEVICH (RU) | 2009-06-25 | — | — | WO | claimed |
| WO-2014012593-A1 | ALKYL SUBSTITUTED 3-HYDROXYPYRIDINES FOR THE TREATMENT OF DEPRESSION | HandelsOrt AG (CH) | 2014-01-23 | — | — | WO | disclosed |
| EP-2231603-B1 | SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | BIRYUKOV DMITRI VALERIEVICH (RU) | 2013-05-01 | — | — | EP | disclosed |
| US-20120270908-A1 | SUBSTITUTED 3 -HYDROZYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | BIRYUKOV DMITRI VALERIEVICH (RU) | 2012-10-25 | — | — | US | disclosed |
| US-20100261764-A1 | SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | BIRYUKOV DMITRI VALERIEVICH | 2010-10-14 | — | — | US | disclosed |
| EP-2231603-A1 | SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | Biryukov, Dmitri Valerievich (RU) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009078746-A1 | SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | BIRYUKOV DMITRI VALERIEVICH (RU) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261764-A1 | SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | GPR119, INSR, IGF1R | HTT 1615/4885KDM4E 1555/4885ALDH1A1 1574/4885 |
| US-20120270908-A1 | SUBSTITUTED 3 -HYDROZYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | GPR119, INSR, IGF1R | HTT 842/4885KDM4E 4009/4885ALDH1A1 2006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.