Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 10/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | STS | P08842 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31148 | 0.88 | HSD17B1 (0.47) | HSD17B2HSD17B1 | |
| SCHEMBL29570 | 0.70 | HSD17B1 (0.71) | HSD17B2HSD17B1 | |
| SCHEMBL18195278 | 0.69 | HSD17B2 (0.65) | HSD17B2HSD17B1MAPK13MAPK12MAPK11 | |
| SCHEMBL23779 | 0.69 | HSD17B2 (0.67) | HSD17B2HSD17B1HDAC6 | |
| SCHEMBL23125 | 0.69 | HSD17B2 (0.65) | HSD17B2HSD17B1ALDH1A1NPC1HPGD | |
| SCHEMBL31108 | 0.67 | HSD17B1 (0.50) | HSD17B2HSD17B1 | |
| SCHEMBL24822 | 0.66 | HDAC6 (0.56) | HSD17B2HSD17B1MAPK13MAPK12MAPK11 | |
| SCHEMBL10395539 | 0.65 | CES2 (0.59) | ALDH1A1STSNPC1HPGDRAB9A | |
| SCHEMBL30620 | 0.65 | HSD17B2 (0.58) | HSD17B2HSD17B1HDAC6 | |
| SCHEMBL23339 | 0.65 | HSD17B2 (0.66) | HSD17B2HSD17B1MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |