Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 17/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.51 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.51 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3052391 | 0.86 | PDK1 (0.53) | PDK1PDK2PDK4PDK3HSP90AA1 | |
| SCHEMBL3054624 | 0.84 | RAB9A (0.55) | PDK1PDK2PDK4PDK3HSP90AA1 | |
| SCHEMBL3058688 | 0.84 | PDK1 (0.56) | PDK1PDK2PDK4PDK3HSP90AA1 | |
| SCHEMBL3065409 | 0.78 | GAA (0.63) | PDK1PDK2PDK4PDK3RAB9A | |
| SCHEMBL5482146 | 0.76 | KMT2A (0.67) | PDK1PDK2PDK4PDK3RAB9A | |
| SCHEMBL3062368 | 0.74 | GAA (0.64) | PDK1GAATSHR | |
| SCHEMBL3055205 | 0.74 | RAB9A (0.58) | PDK1PDK2PDK4PDK3RAB9A | |
| SCHEMBL3056327 | 0.73 | PDK1 (0.55) | PDK1PDK2PDK4PDK3RAB9A | |
| SCHEMBL3049960 | 0.73 | PDK1 (0.52) | PDK1PDK2PDK4PDK3RAB9A | |
| SCHEMBL3061621 | 0.72 | GAA (0.55) | PDK1PDK2PDK4PDK3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261758-A1 | HETEROCYCLIC AMIDES FOR USE AS PHARMACEUTICALS | NOVARTIS AG (CH) | 2010-10-14 | — | — | US | disclosed |
| CN-101405268-A | Amide derivatives and their use for the treatment of protein-related diseases | NOVARTIS AG (CH) | 2009-04-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261758-A1 | HETEROCYCLIC AMIDES FOR USE AS PHARMACEUTICALS | HRH4, CNR1, CNR2 | PDK1 2335/4885PDK2 2110/4885PDK4 1713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.